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雷纳·索菲亚医院在肺叶移植方面的经验。

Experience of the Reina Sofia hospital in lobar lung transplantation.

作者信息

Espinosa D, Algar F J, Moreno P, Illana J, Alvarez A, Cerezo F, Baamonde C, Santos F, Vaquero J M, Redel J, Salvatierra A

机构信息

Hospital Universitario Reina Sofía, University of Cordoba, Cordoba, Spain.

出版信息

Transplant Proc. 2010 Oct;42(8):3214-6. doi: 10.1016/j.transproceed.2010.05.048.

Abstract

The number of patients awaiting lung transplantation has steadily increased over the past decade, but the number of donors has remained relatively stable. Owing to the increasing scarcity of donor lungs, especially for pediatric and small adult recipients, advanced operative strategies for the use of larger grafts for smaller recipients have been developed. Size matching between donors and recipients represents one of the organ distribution criteria widely accepted by lung transplantation teams. However, in some cases it is not possible to allocate a donor to the corresponding size-compatible recipient. To avoid possible complications derived from the implantation of oversized lungs into smaller recipients, various methods of downsizing are applied for cadaveric donor lungs, such as lobar transplantation. We review our experience in 6 patients undergoing volume reduction of the lung graft by lobar resection at the time of transplantation. Graft volume reduction by anatomic resection (lobar transplantation) is a reliable and safe procedure to overcome size disparities between the donor and the recipient of a lung transplant, and thus to maximize the number of donors.

摘要

在过去十年中,等待肺移植的患者数量稳步增加,但供体数量相对保持稳定。由于供体肺日益稀缺,尤其是对于儿科和成年小体型受者而言,已开发出将较大移植物用于较小受者的先进手术策略。供体与受者之间的尺寸匹配是肺移植团队广泛接受的器官分配标准之一。然而,在某些情况下,无法将供体分配给尺寸匹配的相应受者。为避免将过大的肺植入较小受者可能产生的并发症,尸体供体肺采用了各种减容方法,如肺叶移植。我们回顾了6例在移植时通过肺叶切除进行肺移植物减容的患者的经验。通过解剖切除(肺叶移植)进行移植物减容是一种可靠且安全的方法,可克服肺移植供体与受者之间的尺寸差异,从而最大限度地增加供体数量。

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