Markiewicz M, Siekiera U, Dzierzak-Mietla M, Zielinska P, Kyrcz-Krzemien S
Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland.
Transplant Proc. 2010 Oct;42(8):3297-300. doi: 10.1016/j.transproceed.2010.07.029.
We searched for immunogenic mismatches of H-Y minor histocompatibility antigens among unrelated HLA-matched donor-recipient pairs and for their association with transplant outcomes. We included 92 patients who were treated with 10/10 HLA allele-matched, unrelated allogeneic hematopoietic stem cell transplantation (alloHSCT). H-Y genotyping was performed in the Regional Blood Center with use of the Dynal Minor Histocompatibility Antigen Typing Kit. H-Y mismatches in the graft-versus-host direction of female donor to male recipient decreased the relapse rate (6% vs 23%; P=.046) and tended to improve disease-free survival (79% vs 44%; P=.067), but it also increased the incidence of chronic graft-versus-host disease (66% vs 38%; P=.02). Thus it influenced the results of alloHSCT from HLA-matched unrelated donors. The results of this study may help to explain the impact of gender differences between donor and recipient in alloHSCT.
我们在不相关的HLA匹配供受者对中寻找H-Y次要组织相容性抗原的免疫原性错配，并研究它们与移植结果的关联。我们纳入了92例接受10/10 HLA等位基因匹配的不相关异基因造血干细胞移植（alloHSCT）治疗的患者。在地区血液中心使用Dynal次要组织相容性抗原分型试剂盒进行H-Y基因分型。女性供者至男性受者的移植物抗宿主方向上的H-Y错配降低了复发率（6%对23%；P = 0.046），并倾向于改善无病生存率（79%对44%；P = 0.067），但也增加了慢性移植物抗宿主病的发生率（66%对38%；P = 0.02）。因此，它影响了来自HLA匹配的不相关供者的alloHSCT结果。本研究结果可能有助于解释供受者性别差异在alloHSCT中的影响。
