Mistlberger R E, Houpt T A, Moore-Ede M C
Department of Physiology and Biophysics, Harvard Medical School, Boston, MA.
Chronobiol Int. 1990;7(5-6):383-91. doi: 10.3109/07420529009059149.
Rats possess a system of circadian oscillators that permit entrainment of circadian activity rhythms independently to 24 hr cycles of light-dark and food access. The nature of interactions between food- and light-entrainable oscillators was examined by observing the generation and persistence of food-entrained circadian rhythms in rats whose light-entrainable rhythms were eliminated by long-term exposure to constant light. Most of these rats showed a delayed generation of food-entrained rhythms and only one of eight animals showed persistence of food associated rhythms during a 4-day food deprivation test. Rats whose light-entrainable rhythms are eliminated by suprachiasmatic nuclei ablation show, in contrast, normal generation and persistence of food-entrained rhythms. The results suggested a disruptive influence of constant light on non-photic entrainment, possibly due to coupling forces between damped light-entrainable oscillators and the food-entrainable oscillators.
大鼠拥有一套昼夜节律振荡器系统，该系统允许其昼夜活动节律分别与明暗周期和进食机会的24小时循环同步。通过观察长期暴露于持续光照下其光同步节律被消除的大鼠中食物同步昼夜节律的产生和持续情况，研究了食物可同步振荡器和光可同步振荡器之间相互作用的性质。在为期4天的食物剥夺试验中，这些大鼠中的大多数表现出食物同步节律的延迟产生，并且八只动物中只有一只表现出与食物相关节律的持续存在。相比之下，视交叉上核被切除而使其光同步节律被消除的大鼠，其食物同步节律的产生和持续情况正常。结果表明持续光照对非光同步有破坏作用，这可能是由于衰减的光可同步振荡器和食物可同步振荡器之间的耦合力所致。
