Division of Hematology and Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Leuk Res. 2011 Feb;35(2):139-44. doi: 10.1016/j.leukres.2010.09.016.
We report a heterogeneous group of very late recurrences of leukemia occurring more than 10 years after initial treatment including 2 cases of childhood acute lymphoblastic leukemia (ALL) which recurred after more than 20 years of remission, 2 cases of donor cell leukemia which developed more than 10 years after allograft for acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS) and 2 cases of chronic myeloid leukemia (CML) relapsing 13 and 17 years after allograft. Case descriptions are followed by a discussion regarding possible mechanisms leading to leukemia recurrence and a review of the literature.
我们报告了一组异质性的非常晚期白血病复发病例，这些病例发生在初始治疗后 10 年以上，包括 2 例儿童急性淋巴细胞白血病（ALL）在缓解 20 多年后复发，2 例供体细胞白血病在急性髓细胞白血病（AML）和高危骨髓增生异常综合征（MDS）异基因移植后 10 多年发展而来，以及 2 例慢性髓细胞白血病（CML）在异基因移植后 13 年和 17 年复发。病例描述后，我们讨论了导致白血病复发的可能机制，并对文献进行了回顾。
