Chrapusta S, Sieinski W, Konopka B, Szamborski J, Paszko Z
Endocrinology Laboratory, Maria Shłodowska-Curie Memorial Cancer Center, Warsaw, Poland.
Eur J Gynaecol Oncol. 1990;11(5):381-7.
Estrogen receptor (ER) and progestin receptor (PR) levels in the myometria and uterine leiomyomata of 26 normally menstruating women were studied. No significant menstrual cycle-related change in ER level was found in the leiomyomata or normal myometria. The ER levels in normal myometria and in cellular leiomyomata, but not in usual leiomyomata, tended to be higher in the follicular phase than in the luteal one. The "cytosolic" PR levels in cellular leiomyomata and in usual leiomyomata with no or with slight hyalinization as well as in their parental myometria were significantly lower in the luteal than in the follicular phase. This was not the case in usual leiomyomata with more intense hyalinization. The findings show that the reactivity of uterine leiomyomata to estrogens and/or progestins may be related to the histological features of the tumors. This should be realized when studying the steroid receptor levels in the tumours and possibly also when planning an endocrine therapy for the leiomyomata.
对26名正常月经周期女性的子宫肌层和子宫肌瘤中的雌激素受体（ER）和孕激素受体（PR）水平进行了研究。在子宫肌瘤或正常子宫肌层中，未发现与月经周期相关的ER水平有显著变化。正常子宫肌层和细胞性子宫肌瘤中的ER水平，而非普通子宫肌瘤中的ER水平，在卵泡期往往高于黄体期。细胞性子宫肌瘤以及无或仅有轻微玻璃样变的普通子宫肌瘤及其母本子宫肌层中的“胞质”PR水平，在黄体期显著低于卵泡期。而玻璃样变更明显的普通子宫肌瘤则并非如此。研究结果表明，子宫肌瘤对雌激素和/或孕激素的反应性可能与肿瘤的组织学特征有关。在研究肿瘤中的类固醇受体水平时，以及在可能为子宫肌瘤规划内分泌治疗时，都应认识到这一点。
