Herrmann F, Peschke E, Peil J, Hambsch K, Sorger D, Herzmann A, Schmidt H E
Policlinical Department, University of Leipzig/GDR.
Exp Clin Endocrinol. 1990 Nov;96(2):157-67. doi: 10.1055/s-0029-1211005.
To investigate biological rhythms of the thyroid gland circannual oscillations of thyroxine (T4), triiodothyronine (T3), and thyrotropin (TSH) were compared in serum samples of untreated young male Wistar-rats with the circannual changes of thyroid weights and with the relative proportion of colloid, epithelium, and interstitium of the thyroids. Animals were kept under standard environmental conditions, however, lighting conditions simulated the natural day-night changes. Thyroid weights, T4, T3, and TSH showed a statistically significant circannual rhythm with maxima in winter and spring and minima in summer and autumn. The same circannual patterns were observed in the proportion of epithelium and interstitium of the thyroids, while the colloid exhibited an inverse circannual pattern. These data were verified by biomathematical methods, like locally adjusted functional approximation, analysis of variance, and Spearman rank correlation. Our results represent an example for the concordance between functional and morphometrical changes in the course of circannual oscillations. Furthermore, these data confirm our earlier results describing higher T4-levels in the winter time (short-day) and lower serum titers in the summer time (long-day).
为研究甲状腺的生物节律，在未处理的年轻雄性Wistar大鼠的血清样本中，比较了甲状腺素（T4）、三碘甲状腺原氨酸（T3）和促甲状腺激素（TSH）的年周期振荡，并将其与甲状腺重量的年周期变化以及甲状腺胶体、上皮和间质的相对比例进行了比较。动物饲养在标准环境条件下，不过光照条件模拟自然昼夜变化。甲状腺重量、T4、T3和TSH呈现出具有统计学意义的年周期节律，冬季和春季达到最大值，夏季和秋季达到最小值。甲状腺上皮和间质的比例呈现相同的年周期模式，而胶体则呈现相反的年周期模式。这些数据通过生物数学方法得到验证，如局部调整函数逼近、方差分析和Spearman等级相关性分析。我们的结果代表了年周期振荡过程中功能和形态测量变化之间一致性的一个例子。此外，这些数据证实了我们早期的结果，即冬季（短日照）T4水平较高，夏季（长日照）血清滴度较低。
