[全身移植物抗宿主反应期间甲状腺的功能状态]

[Functional state of the thyroid gland during systemic graft vs host reaction].

作者信息

Kozlova T D, Fedorov G N, Molotkov O V

出版信息

Biull Eksp Biol Med. 1985 Nov;100(11):595-7.

Abstract

Triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) serum content was measured in mice during systemic "graft-versus-host" reaction (GVHR), using radioimmunoassay. It was demonstrated that on the 3rd day after GVHR induction the levels of these hormones did not differ from the control values. T3 and T4 concentrations and 125I absorption by thyroid gland diminished by day 10. At the same time TSH level remained unchanged. On day 24 after GVHR induction T3 and T4 content was significantly reduced, although TSH concentration exceeded the control value. 125I absorption was enhanced as compared to the value observed on day 10. The data obtained show the vigorous inhibition of thyroid gland function during systemic GVHR.

摘要

采用放射免疫分析法，测定了小鼠在全身性“移植物抗宿主”反应（GVHR）期间血清中三碘甲状腺原氨酸（T3）、甲状腺素（T4）和促甲状腺激素（TSH）的含量。结果表明，在诱导GVHR后的第3天，这些激素的水平与对照值无差异。到第10天，T3和T4浓度以及甲状腺对125I的摄取量降低。与此同时，TSH水平保持不变。在诱导GVHR后的第24天，T3和T4含量显著降低，尽管TSH浓度超过对照值。与第10天观察到的值相比，125I摄取增强。所获得的数据表明，在全身性GVHR期间甲状腺功能受到强烈抑制。