Carfagna N, Moretti A
Farmitalia Carlo Erba Research Center, Nerviano, Italy.
Exp Gerontol. 1990;25(6):545-52. doi: 10.1016/0531-5565(90)90020-3.
The content and synthesis of GABA were measured in the cortex and striatum of young adult (4 months), mature (14 months), and old (24 months) male Wistar rats. GABA synthesis was determined from the GABA accumulation induced by aminooxyacetic acid (AOAA). Aging did not affect GABA content in the cortex (1.03 +/- 0.04 mumoles/g in young and 1.06 +/- 0.04 mumoles/g in old rats), or in the striatum (1.63 +/- 0.04 mumoles/g in young and 1.56 +/- 0.05 mumoles/g in old rats). Aging did not significantly change the AOAA-induced GABA accumulation in the striatum (+34% in young, +16% in mature, and +28% in old rats), but significantly reduced it in the cortex where this process takes place to a greater extent than in the striatum: +164% in young, +116% in mature, and +120% in old animals. It can be concluded that while in the striatum aging did not affect AOAA-induced GABA accumulation, in the cortex this was less in mature than young rats, with no further change in the old ones. GABA content was not affected by aging in either region.
在年轻成年（4个月）、成熟（14个月）和老年（24个月）雄性Wistar大鼠的皮质和纹状体中测量了γ-氨基丁酸（GABA）的含量及合成情况。通过氨氧基乙酸（AOAA）诱导的GABA积累来测定GABA合成。衰老并未影响皮质中的GABA含量（年轻大鼠为1.03±0.04微摩尔/克，老年大鼠为1.06±0.04微摩尔/克），也未影响纹状体中的GABA含量（年轻大鼠为1.63±0.04微摩尔/克，老年大鼠为1.56±0.05微摩尔/克）。衰老并未显著改变AOAA诱导的纹状体中GABA的积累（年轻大鼠增加34%，成熟大鼠增加16%，老年大鼠增加28%），但显著降低了皮质中AOAA诱导的GABA积累，且该过程在皮质中比在纹状体中发生的程度更大：年轻动物增加164%，成熟动物增加116%，老年动物增加120%。可以得出结论，虽然在纹状体中衰老并未影响AOAA诱导的GABA积累，但在皮质中，成熟大鼠的这种积累比年轻大鼠少，老年大鼠则没有进一步变化。两个区域的GABA含量均未受衰老影响。
