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虹膜切除术后青光眼的激发试验与药物治疗

Provocation and medical treatment in post-iridectomy glaucoma.

作者信息

Hung P T

机构信息

Department of Ophthalmology, Taiwan University Hospital, Taipei, Republic of China.

出版信息

J Ocul Pharmacol. 1990 Winter;6(4):279-83. doi: 10.1089/jop.1990.6.279.

Abstract

Residual glaucoma after an iridectomy in primary angle-closure glaucoma, or so called post-iridectomy glaucoma, is rather well recognized recently. It is also realized that probably different mechanisms in addition to the pupillary block mechanism co-exist in the same glaucoma eye. The efficacy of medical treatment for such glaucoma was evaluated by dark prone provocative test after timolol or pilocarpine topical instillation to compare with non-medication as control in 72 iridectomized eyes. The results revealed pilocarpine medication has only six eyes positive (8.3%) and significantly prevents IOP elevation in the test while timolol has no significant effect (23 eyes positive, 31.9%) when both were compared with the control study (31 eyes positive, 43.1%). The results may also suggest additional different mechanisms involved in this glaucoma.

摘要

原发性闭角型青光眼虹膜切除术后的残余性青光眼,即所谓的虹膜切除术后青光眼,近年来已得到较为充分的认识。人们也认识到,除瞳孔阻滞机制外,同一青光眼眼中可能还存在不同的机制。对72只接受虹膜切除术的眼睛,在局部滴用噻吗洛尔或毛果芸香碱后,通过暗俯卧激发试验评估这种青光眼的药物治疗效果,并与未用药作为对照进行比较。结果显示,与对照研究(31只眼睛阳性,43.1%)相比,毛果芸香碱用药仅有6只眼睛阳性(8.3%),且在试验中能显著预防眼压升高,而噻吗洛尔则无显著效果(23只眼睛阳性,31.9%)。这些结果也可能提示该青光眼存在其他不同的机制。

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