Abaev Iu K
Vestn Khir Im I I Grek. 2010;169(4):61-5.
A comparative study of frequency, structure and specific features of the clinical course was fulfilled in 2456 children with surgical infection of bones and joints (SIBJ) in the period from 1970 to 1985 and 1986 to 2006. The work used clinical, instrumental, radiation, laboratory, microbiological, immunological and statistical methods of investigations. Specific features of SIBJ in children at the present time are: 1) pathomorphosis of hematogenic osteomyelitis; 2) the appearance of previously not noted new forms of SIBJ--fetal osteomyelitis and arthritis, chronic recurring multifocal osteomyelitis, syndrome SAPHO and increasing frequency of previously rare BCG-osteomyelitis, exogenous osteomyelitis, sacroiliitis and inervertebral disciitis; 3) widening the spectrum of SIBJ pathogens with an increasing significance of involutionary forms of bacteria, elevation of their resistence to antibiotics and antiseptics, increase of the factors promoting the development of immunodeficient states in childhood.
对1970年至1985年以及1986年至2006年期间2456例患有骨与关节外科感染(SIBJ)的儿童,进行了临床病程的频率、结构和特征的比较研究。该研究采用了临床、仪器、放射、实验室、微生物、免疫和统计调查方法。目前儿童SIBJ的特征如下:1)血源性骨髓炎的病理形态;2)出现了以前未发现的SIBJ新形式——胎儿骨髓炎和关节炎、慢性复发性多灶性骨髓炎、SAPHO综合征,以及以前罕见的卡介苗骨髓炎、外源性骨髓炎、骶髂关节炎和椎间盘炎的发病率增加;3)SIBJ病原体谱扩大,细菌退化形式的重要性增加,它们对抗生素和防腐剂的耐药性提高,促进儿童免疫缺陷状态发展的因素增多。