Wallack Seth, Metcalf Michelle, Skidmore Angela, Lamb Christopher R
VICSD, Radiology, 7522 Clairemont Mesa Blvd., San Diego, CA 92111, USA.
Vet Radiol Ultrasound. 2010 Sep-Oct;51(5):554-60. doi: 10.1111/j.1740-8261.2010.01699.x.
Feline hyperthyroidism is a common endocrine disorder. A single dose of 148MBq (4mCi) 131I is 95-98% effective for the treatment of hyperthyroidism in cats; however, the cause for treatment failures has not been determined. In a series of 113 hyperthyroid cats having pertechnetate thyroid scintigraphy before treatment using a standard 148MBq (4mCi) 131I dose, the thyroid to salivary gland (T:S) ratio and the thyroid to background (T:B) ratio were calculated. Results in 107 (95%) cats successfully treated were compared with results in six (5%) cats that remained hyperthyroid after treatment. T:B ratio was significantly higher for cats that had treatment failure (median 13.0, range 3.6-73.0) than for cats successfully treated (median 4.4, range 1.2-69.0) (P = 0.02), whereas there was no significant difference in their T:S ratios (P = 0.2). The T:B ratio is a new approach to evaluating the thyroid pertechnetate scan with the intent of identifying which hyperthyroid cats may fail treatment using a standard 148 MBq (4 mCi) 131 dose and which, therefore, require a higher dose.
猫甲状腺功能亢进是一种常见的内分泌疾病。单次给予148MBq（4mCi）的131I对治疗猫的甲状腺功能亢进有效率为95 - 98%；然而，治疗失败的原因尚未确定。在一系列113只甲状腺功能亢进的猫中，在使用标准的148MBq（4mCi）131I剂量进行治疗前进行了高锝酸盐甲状腺闪烁扫描，并计算了甲状腺与唾液腺（T:S）比值和甲状腺与本底（T:B）比值。将107只（95%）成功治疗的猫的结果与6只（5%）治疗后仍为甲状腺功能亢进的猫的结果进行比较。治疗失败的猫的T:B比值（中位数13.0，范围3.6 - 73.0）显著高于成功治疗的猫（中位数4.4，范围1.2 - 69.0）（P = 0.02），而它们的T:S比值没有显著差异（P = 0.2）。T:B比值是一种评估甲状腺高锝酸盐扫描的新方法，旨在确定哪些甲状腺功能亢进的猫使用标准的148MBq（4mCi）131I剂量治疗可能失败，因此哪些猫需要更高的剂量。
