Peterson Mark E, Broome Michael R
Animal Endocrine Clinic, New York, New York.
Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):84-95. doi: 10.1111/vru.12165. Epub 2014 May 2.
Thyroid scintigraphy is currently the reference standard for diagnosing and staging cats with hyperthyroidism, but few studies describing the scintigraphic characteristics in a large number of cats have been reported. The objective of this study was to better characterize thyroid scintigraphy findings by evaluating 2096 consecutive cats with hyperthyroidism that were referred over a 3.5-year period. Of these cats, 2068 (98.7%) had a high thyroid-to-salivary ratio (>1.5), whereas 2014 (96.1%) were found to have a high thyroid-to-background ratio (>6.1). When the patterns of the cats' thyroid disease were recorded, 665 (31.7%) had unilateral disease, 1060 (50.6%) had bilateral-asymmetric disease (two thyroid lobes unequal in size), 257 (12.3%) had bilateral-symmetric disease (both lobes similar in size), and 81 (3.9%) had multifocal disease (≥3 areas of increased radionuclide uptake). The number of areas of (99m) TcO(-) 4 uptake in the 2096 cats ranged from 1 to 6 (median, 2), located in the cervical area in 2057 (98.1%), thoracic inlet in 282 (13.5%), and in the thoracic cavity in 115 (5.5%). Ectopic thyroid tissue (e.g. lingual or mediastinal) was diagnosed in 81 (3.9%) cats, whereas thyroid carcinoma was suspected in 35 (1.7%) of the cats. The results of this study support conclusions that most hyperthyroid cats have unilateral or bilateral thyroid nodules, but that multifocal disease will develop in a few cats that have ectopic thyroid disease or thyroid carcinoma. Both ectopic thyroid disease and thyroid carcinoma are relatively uncommon in hyperthyroid cats, with a respective prevalence of ∼4% and ∼2% in this study.
甲状腺闪烁扫描术目前是诊断猫甲状腺功能亢进症及进行分期的参考标准，但鲜有研究报道大量猫的闪烁扫描特征。本研究的目的是通过评估在3.5年期间转诊的2096只连续患有甲状腺功能亢进症的猫，更好地描述甲状腺闪烁扫描的结果。在这些猫中，2068只（98.7%）的甲状腺与唾液腺比值较高（>1.5），而2014只（96.1%）的甲状腺与背景比值较高（>6.1）。记录猫的甲状腺疾病模式时，665只（31.7%）患有单侧疾病，1060只（50.6%）患有双侧不对称疾病（两个甲状腺叶大小不等），257只（12.3%）患有双侧对称疾病（两个叶大小相似），81只（3.9%）患有多灶性疾病（≥3个放射性核素摄取增加区域）。2096只猫中（99m）TcO4摄取区域的数量为1至6个（中位数为2个），位于颈部区域的有2057只（98.1%），位于胸廓入口的有282只（13.5%），位于胸腔的有115只（5.5%）。81只（3.9%）猫被诊断为异位甲状腺组织（如舌部或纵隔），而35只（1.7%）猫疑似患有甲状腺癌。本研究结果支持以下结论：大多数甲状腺功能亢进的猫有单侧或双侧甲状腺结节，但少数患有异位甲状腺疾病或甲状腺癌的猫会发展为多灶性疾病。异位甲状腺疾病和甲状腺癌在甲状腺功能亢进的猫中相对不常见，在本研究中的患病率分别约为4%和2%。
