Department of Chemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.
J Org Chem. 2010 Nov 19;75(22):7887-92. doi: 10.1021/jo1017074. Epub 2010 Oct 25.
N,N',N''-trimethyltribenzo-1,4,7-triazacyclononatriene has been synthesized via sequential palladium-catalyzed Buchwald-Hartwig N-arylation reactions affording the 9-membered triaza o-cyclophane in 35% overall yield. An X-ray crystal structure shows the new cyclophane to have a C2-symmetric saddle conformation, as compared to the crown conformation exhibited by the related carbocyclic cyclotriveratrylene (CTV).
N,N',N''-三甲基三苯并-1,4,7-三氮杂环壬三烯通过顺序钯催化 Buchwald-Hartwig N-芳基化反应合成，总收率为 35%，得到 9 元三氮杂 o-环笼。X 射线晶体结构表明，与相关的碳环环三亚芴（CTV）表现出的冠构象相比，新的环笼具有 C2 对称的鞍形构象。
