Vidémont E, Pin D
Unité Dermatologie, VetAgro Sup Campus Vétérinaire de Lyon, Marcy l'Etoile F-69280, France.
J Small Anim Pract. 2010 Nov;51(11):599-603. doi: 10.1111/j.1748-5827.2010.00999.x.
Otitis externa in cats is relatively uncommon. This report describes a case of a rare, visually distinctive, proliferative and necrotising otitis in a three-month-old Persian kitten. The cat had proliferative, erythematous and necrotic tissue covering most of the proximal pinnae and vertical ear canals. On histopathological examination, the most striking feature was the existence of scattered apoptotic-appearing keratinocytes within severely hyperplastic epithelium. For the first time, immunohistochemistry was used to show a closed association between CD3(+) T cells and caspase-3 stained keratinocytes, consistent with a keratinocyte apoptosis by epidermal-infiltrating T cells. Treatment was initiated using topical tacrolimus twice daily and an ear cleanser once daily. A marked improvement was observed after 10 days of treatment and the lesions completely resolved over a period of three weeks. The origin of T cells directed against keratinocytes is currently unknown.
猫外耳炎相对不常见。本报告描述了一例三个月大的波斯小猫罕见的、外观独特的、增生性和坏死性耳炎病例。这只猫的大部分近端耳廓和垂直耳道覆盖着增生性、红斑性和坏死性组织。组织病理学检查显示，最显著的特征是在严重增生的上皮内存在散在的凋亡样角质形成细胞。首次使用免疫组织化学显示CD3(+) T细胞与半胱天冬酶-3染色的角质形成细胞之间存在紧密关联，这与表皮浸润性T细胞导致的角质形成细胞凋亡一致。治疗开始时，每天两次局部使用他克莫司，每天一次使用耳部清洁剂。治疗10天后观察到明显改善，病变在三周内完全消退。针对角质形成细胞的T细胞来源目前尚不清楚。
