Unité de Neuroimagerie Fonctionnelle, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada.
Behav Brain Res. 2011 Feb 2;217(1):117-21. doi: 10.1016/j.bbr.2010.10.019. Epub 2010 Oct 23.
This study aimed to determine the distinct contribution of slow (11-13 Hz) and fast (13-15 Hz) spindles in the consolidation process of a motor sequence learning task (MSL). Young subjects (n = 12) were trained on both a finger MSL task and a control (CTRL) condition, which were administered one week apart in a counterbalanced order. Subjects were asked to practice the MSL or CTRL task in the evening (approximately 9:00 p.m.) and their performance was retested on the same task 12h later (approximately 9:00 a.m.). Polysomnographic (PSG) recordings were performed during the night following training on either task, and an automatic algorithm was used to detect fast and slow spindles and to quantify their characteristics (i.e., density, amplitude, and duration). Statistical analyses revealed higher fast (but not slow) spindle density after training on the MSL than after practice of the CTRL task. The increase in fast spindle density on the MSL task correlated positively with overnight performance gains on the MSL task and with difference in performance gain between the MSL and CTRL tasks. Together, these results suggest that fast sleep spindles help activate the cerebral network involved in overnight MSL consolidation, while slow spindles do not appear to play a role in this mnemonic process.
本研究旨在确定慢（11-13 Hz）和快（13-15 Hz）纺锤波在运动序列学习任务（MSL）的巩固过程中的独特贡献。年轻受试者（n=12）在手指 MSL 任务和对照（CTRL）条件下进行训练，两种条件以平衡的顺序相隔一周进行。要求受试者在晚上（大约 9:00 p.m.）练习 MSL 或 CTRL 任务，并在 12 小时后（大约 9:00 a.m.）对相同任务进行重新测试。在训练后的晚上进行多导睡眠图（PSG）记录，使用自动算法检测快和慢纺锤波，并量化它们的特征（即密度、幅度和持续时间）。统计分析显示，在 MSL 任务上进行训练后，快（但不是慢）纺锤波的密度更高。MSL 任务上快纺锤波密度的增加与 MSL 任务的夜间表现增益呈正相关，与 MSL 和 CTRL 任务之间的表现增益差异呈正相关。这些结果表明，快睡眠纺锤波有助于激活参与夜间 MSL 巩固的大脑网络，而慢纺锤波似乎在这个记忆过程中不起作用。
