Oliveira Lisiane dos Santos, da Silva Ligia Pereira, da Silva Aline Isabel, Magalhães Carolina Peixoto, de Souza Sandra Lopes, de Castro Raul Manhães
Centro Acadêmico de Vitória - Universidade Federal de Pernambuco, Vitória de Santo Antão - PE, Brazil.
Behav Processes. 2011 Jan;86(1):119-24. doi: 10.1016/j.beproc.2010.10.001. Epub 2010 Oct 23.
The objective of this work was to study the effect of early weaning on circadian rhythm and the behavioral satiety sequence in adult rats. Male Wistar rat pups were weaned for separation from the mother at 15 (D15), 21 (D21) and 30 (D30) days old. Body weight and food intake was measured every 30 days until pups were 150 days old. At 90 days of age, the circadian rhythm of food intake was evaluated every 4h for three days. Behavioral satiety was evaluated at 35 and 100 days of age. This work demonstrated that body weight and food intake were not altered, but the behavioral satiety sequence demonstrated that the D15 group delayed satiety compared with the D30 group at 100 days of age. In the circadian rhythm of the food intake study, early weaning (D15) changed food intake in the intermediary period of the light phase and in the intermediary period of the dark phase. In conclusion, our study showed that early weaning may alter the feeding behavior mainly in relation to satiety and the circadian rhythm of feeding. It is possible that the presence of other environmental stimuli during early weaning can cause hyperphagia and deregulate the mechanisms of homeostasis and body weight control. This study supports theories that depict insults during early life as determinants of chronic diseases.
这项工作的目的是研究早期断奶对成年大鼠昼夜节律和行为饱腹感序列的影响。雄性Wistar大鼠幼崽在15日龄（D15）、21日龄（D21）和30日龄（D30）时断奶与母亲分离。每30天测量一次体重和食物摄入量，直到幼崽150日龄。在90日龄时，连续三天每4小时评估一次食物摄入的昼夜节律。在35日龄和100日龄时评估行为饱腹感。这项研究表明，体重和食物摄入量没有改变，但行为饱腹感序列表明，在100日龄时，D15组与D30组相比饱腹感延迟。在食物摄入昼夜节律研究中，早期断奶（D15）改变了光照期中间阶段和黑暗期中间阶段的食物摄入量。总之，我们的研究表明，早期断奶可能主要在饱腹感和进食昼夜节律方面改变进食行为。早期断奶期间存在其他环境刺激可能导致食欲亢进，并使体内平衡和体重控制机制失调。这项研究支持了将生命早期的损伤描述为慢性疾病决定因素的理论。
