Department of Thoracic Surgery, Georges Pompidou European Hospital, 20 rue Leblanc, 75015, Paris, France.
Thorac Surg Clin. 2010 Nov;20(4):519-27. doi: 10.1016/j.thorsurg.2010.06.004.
Non-Small cell lung cancer invading the chest wall represents an advanced stage of the disease. Chest wall resection may be achieved in up to 100% of the patients, and the ensuing defect requires to be reconstructed in 40% to 64% of cases. Once a surgical challenge, chest wall resection is no longer a technical problem and en bloc chest wall and lung resections regularly provide good results. However, survival rates are jeopardized by incompleteness of the resection and mediastinal lymph node involvement. Nowadays, the challenge is represented by the use of the other nonsurgical modalities (chemotherapy and radiation therapy) to increase the chance of performing a complete resection, the need to achieve a better control of probable lymphatic or hematogenous spread, and the reduction of the recurrence rate.
非小细胞肺癌侵犯胸壁代表疾病的晚期。胸壁切除术在多达 100%的患者中可以实现，而 40%至 64%的患者需要对随之而来的缺损进行重建。胸壁切除术曾经是一项具有挑战性的手术，但现在已不再是技术难题，整块胸壁和肺切除术通常可以取得良好的效果。然而，由于切除不完全和纵隔淋巴结受累，生存率仍受到威胁。如今，挑战在于使用其他非手术方式（化疗和放疗）来增加完全切除的机会，需要更好地控制可能的淋巴或血行播散，并降低复发率。
