Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza, P.le A. Moro 5, 00185 Roma, Italy.
Eur J Med Chem. 2010 Dec;45(12):6135-8. doi: 10.1016/j.ejmech.2010.10.005. Epub 2010 Oct 25.
Eighteen new 1-N-substituted-3,5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been evaluated. The results of these biological assays showed that all of new derivatives are not endowed with improved anti-inflammatory activity against COX-1, but some of them showed a good activity against COX-2. To evaluate the binding mode of the most significative compounds (2d, 2f, 2g and 2k) docking studies were carried out. These studies confirmed biological data, in fact these compounds were able to fit into the active site of COX-2.
已经合成了十八种新的 1-N-取代的 3,5-二苯基-2-吡唑啉衍生物，并评估了它们对环氧化酶（COX-1 和 COX-2）的抑制活性。这些生物测定的结果表明，所有的新衍生物都没有改善对 COX-1 的抗炎活性，但其中一些对 COX-2 表现出良好的活性。为了评估最有意义的化合物（2d、2f、2g 和 2k）的结合模式，进行了对接研究。这些研究证实了生物学数据，事实上，这些化合物能够与 COX-2 的活性位点结合。
