Sun S L, Cheng K W, Chien C C, Che C J, Chang C F
Department of Anesthesia, Cathay General Hospital, Taiwan, R.O.C.
Ma Zui Xue Za Zhi. 1990 Dec;28(4):433-7.
Ninety paturients undergoing elective cesarean section were included in this randomized study to compare the influence of the injected volume of epidural morphine (EM) on postoperative analgesia. Three similar groups of patients (n = 30 each) received 2 mg EM in 2 ml, 10 ml, and 20 ml saline respectively one hour after the last dose of 2% lidocaine. Pain scores (0-10) at rest (including uterine contraction pain) at the 2nd, 4th, 8th, 12th, 18th, and 24th h were compared among the three groups. There were no statistically significant differences of pain score among the three groups although lower pain score was present in the 20 ml group since the 8th h and thereafter. Regarding the number of patients who requested additional meperidine for pain relief 3 in 2 ml group, 2 in 10 ml group and 1 in 20 ml group respectively. The result may suggest that the influence of the injected volume of EM on postcesarean analgesia is not obvious.
本随机研究纳入了90例行择期剖宫产的患者，以比较硬膜外吗啡（EM）注射剂量对术后镇痛的影响。三组相似的患者（每组n = 30）在最后一剂2%利多卡因注射1小时后，分别接受了2 mg EM加2 ml、10 ml和20 ml生理盐水。比较了三组在第2、4、8、12、18和24小时静息时（包括子宫收缩痛）的疼痛评分（0 - 10分）。尽管自第8小时及之后20 ml组的疼痛评分较低，但三组之间的疼痛评分无统计学显著差异。关于因疼痛需要额外注射哌替啶的患者数量，2 ml组有3例，10 ml组有2例，20 ml组有1例。结果可能提示EM注射剂量对剖宫产术后镇痛的影响不明显。
