Pitiakoudis Michail, Zezos Petros, Courcoutsakis Nikos, Papanas Nikolaos, Giatromanolaki Alexandra, Sivridis Efthimios, Kouklakis Georgios, Simopoulos Constantinos
2nd Department of Surgery, Democritus University of Thrace, University General Hospital of Alexanroupolis, Dragana Alexandroupolis, Greece.
Surg Laparosc Endosc Percutan Tech. 2010 Oct;20(5):e160-3. doi: 10.1097/SLE.0b013e3181f334ca.
A 51-year-old female patient presented with iron deficiency anemia. Upper and lower gastrointestinal endoscopy were unremarkable. Computed tomography enteroclysis showed an ovoid 3×4-cm jejunal tumor with intraluminal protrusion and exophytic growth pattern, without lymphadenopathy or metastatic disease. Laparoscopic resection of the tumor was successfully carried out. Histologically, a mesenchymal tumor composed of spindle cells with an interlacing bundle pattern and high-mitotic activity greater than 10 mitoses/50 high-power fields were observed. The immunohistochemistry showed that the tumor was KIT (CD117)-, vimentin-, smooth muscle actin-, and S-100-positive, whereas it was CD34-negative. These findings were consistent with the features of a gastrointestinal stromal tumor. The patient had an uneventful postoperative course, and after 10 months of follow-up, she is well without any evidence of tumor recurrence.
一名51岁女性患者表现为缺铁性贫血。上、下消化道内镜检查未见异常。计算机断层扫描小肠造影显示空肠有一个3×4厘米的椭圆形肿瘤，呈腔内突出和外生性生长模式，无淋巴结肿大或转移病灶。成功进行了腹腔镜肿瘤切除术。组织学上，观察到一个由梭形细胞组成的间叶性肿瘤，呈交错束状模式，有丝分裂活性高，大于10个有丝分裂/50个高倍视野。免疫组化显示肿瘤KIT（CD117）、波形蛋白、平滑肌肌动蛋白和S-100呈阳性，而CD34呈阴性。这些发现与胃肠道间质瘤的特征相符。患者术后病程平稳，随访10个月后，情况良好，无肿瘤复发迹象。
