Abreu Pedro, Duarte Cátia, Malcata Armando
Serviço de Reumatologia – Hospitais da Universidade de Coimbra, Coimbra.
Acta Reumatol Port. 2010 Jul-Sep;35(3):366-9.
The authors present a case of a man with 62 years of age who comes to the emergency room by purple skin lesions affecting the whole body, including palmar-plantar involvement, with insidious installation, with three weeks of development. Physical examination revealed multiple purple-shaping round and confluent lesions involving the entire body. Laboratory tests performed were all normal. During the admission a skin biopsy was performed. After exclusion of other causes for the purpuric lesions, the acenocoumarol was interrupted and the lesions disappeared, spontaneously, in a week. The purple was attributed to the administration of acenocoumarol, given the resolution of lesions, despite the chronicity of therapy. This case illustrates a rare association between vasculitis and acenocoumarol.
作者报告了一例62岁男性患者,因全身出现紫色皮肤病变前来急诊室,包括掌跖受累,起病隐匿,病程3周。体格检查发现全身有多个圆形且融合的紫色病变。所做的实验室检查均正常。住院期间进行了皮肤活检。排除紫癜性病变的其他病因后,停用醋硝香豆素,病变在一周内自行消失。尽管治疗时间较长,但鉴于病变消退,紫色皮肤病变归因于醋硝香豆素的使用。该病例说明了血管炎与醋硝香豆素之间一种罕见的关联。