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本文引用的文献

1
Extended drotrecogin alfa (activated) treatment in patients with prolonged septic shock.在脓毒性休克持续时间较长的患者中延长活化蛋白C治疗。
Intensive Care Med. 2009 Jul;35(7):1187-95. doi: 10.1007/s00134-009-1436-1. Epub 2009 Mar 5.
2
Recombinant human activated protein C, package labeling, and hemorrhage risks.重组人活化蛋白C、包装标签与出血风险。
Crit Care Med. 2009 Jan;37(1):327-9. doi: 10.1097/CCM.0b013e3181935102.
3
Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions.在严重脓毒症患者中使用活化蛋白C(drotrecogin alfa)及基线出血预防措施相关的不良结局。
Crit Care Med. 2009 Jan;37(1):19-25. doi: 10.1097/CCM.0b013e318192843b.
4
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.一项关于活化蛋白C用于持续性感染性休克的多国安慰剂对照试验的设计、实施、分析及报告。
Intensive Care Med. 2008 Nov;34(11):1935-47. doi: 10.1007/s00134-008-1266-6. Epub 2008 Oct 7.
5
Human recombinant activated protein C for severe sepsis.用于严重脓毒症的重组人活化蛋白C
Cochrane Database Syst Rev. 2008 Jan 23(1):CD004388. doi: 10.1002/14651858.CD004388.pub3.
6
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated).在接受活化蛋白C治疗的严重脓毒症患者中预防性使用肝素。
Am J Respir Crit Care Med. 2007 Sep 1;176(5):483-90. doi: 10.1164/rccm.200612-1803OC. Epub 2007 Jun 7.
7
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial.重组人活化蛋白C用于儿童严重脓毒症治疗:一项多中心III期随机对照试验
Lancet. 2007 Mar 10;369(9564):836-843. doi: 10.1016/S0140-6736(07)60411-5.
8
Can we RESOLVE the treatment of sepsis?我们能解决败血症的治疗问题吗?
Lancet. 2007 Mar 10;369(9564):803-804. doi: 10.1016/S0140-6736(07)60383-3.
9
Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study.评估重组人活化蛋白C在成人严重脓毒症中的应用:一项加拿大多中心观察性研究。
Intensive Care Med. 2007 Mar;33(3):517-23. doi: 10.1007/s00134-007-0555-9. Epub 2007 Feb 15.
10
Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey.意大利重症监护病房中活化蛋白C(重组人活化蛋白C)的使用情况:一项全国性调查的结果
Intensive Care Med. 2007 Mar;33(3):426-34. doi: 10.1007/s00134-007-0554-x. Epub 2007 Feb 15.

An update on activated protein C (xigris) in the management of sepsis.

作者信息

Alaniz Cesar

机构信息

Dr. Alaniz is a Clinical Pharmacist and Clinical Associate Professor at the University of Michigan Hospitals and College of Pharmacy in Ann Arbor, Michigan.

出版信息

P T. 2010 Sep;35(9):504-29.

PMID:20975809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2957744/
Abstract
摘要