用于合成手性氮杂环的未活化烯烃、二烯、联烯和炔烃的对映选择性分子内胺化官能团化反应。
The enantioselective intramolecular aminative functionalization of unactivated alkenes, dienes, allenes and alkynes for the synthesis of chiral nitrogen heterocycles.
作者信息
Chemler Sherry R
机构信息
Department of Chemistry, 618 Natural Science Complex, The University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
出版信息
Org Biomol Chem. 2009;7(15):3009-3019. doi: 10.1039/B907743J.
Abstract
The enantioselective intramolecular aminative functionalization of unactivated alkenes and related π-systems is a straight-forward and atom economical strategy for the synthesis of chiral nitrogen heterocycles. These reactions can be categorized as oxidatively neutral, such as alkene hydroamination, or as oxidative reactions, such as alkene difunctionalization, e.g. aminooxygenation and carboamination. This perspective reviews the current work in the field and explores mechanistic trends that are common among the different catalysts and reaction types.
摘要
未活化烯烃及相关π体系的对映选择性分子内胺化官能团化反应是合成手性含氮杂环化合物的一种直接且原子经济的策略。这些反应可分为氧化中性反应，如烯烃氢胺化反应，或氧化反应，如烯烃双官能团化反应，例如氨氧化反应和碳胺化反应。本文综述了该领域的当前研究工作，并探讨了不同催化剂和反应类型中常见的机理趋势。
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