用于不对称分子内烯烃氢胺化反应的双（酰胺基）锆催化剂
Zirconium Bis(Amido) Catalysts for Asymmetric Intramolecular Alkene Hydroamination.
作者信息
Watson Donald A, Chiu Melanie, Bergman Robert G
机构信息
Department of Chemistry, University of California, Berkeley, California 94720-1460,
出版信息
Organometallics. 2006 Sep 25;25(20):4731-4733. doi: 10.1021/om0606791.
Abstract
In situ combination of diphosphinic amides and Zr(NMe(2))(4) results in the formation of chiral zirconium bis(amido) complexes. The complexes are competent catalysts for intramolecular asymmetric alkene hydroamintion, providing piperidines and pyrrolidines in up to 80% ee and high yield. This system utilizes an inexpensive zirconium precatalyst and readily prepared ligands and is the first asymmetric alkene hydroamination catalyst based upon a neutral zirconium bis(amido) complex.
摘要
二膦酰胺与Zr(NMe(2))(4)的原位组合导致手性双（酰胺基）锆配合物的形成。这些配合物是分子内不对称烯烃氢胺化反应的有效催化剂，能以高达80%的对映体过量和高产率提供哌啶和吡咯烷。该体系使用一种廉价的锆预催化剂和易于制备的配体，是首个基于中性双（酰胺基）锆配合物的不对称烯烃氢胺化催化剂。
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