中风后的炎症反应：机制与治疗策略。
Inflammation after stroke: mechanisms and therapeutic approaches.
机构信息
Geriatric Research Educational and Clinical Center (00-GR-H), V.A. Pittsburgh Healthcare System, 7180 Highland Drive, Pittsburgh, PA 15206, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Transl Stroke Res. 2010 Jun;1(2):74-84. doi: 10.1007/s12975-010-0023-7.
Abstract
Reperfusion of ischemic brain can reduce injury and improve outcome, but secondary injury due to inflammatory mechanisms limits the efficacy and time window of such treatments for stroke. This review summarizes the cellular and molecular basis of inflammation in ischemic injury as well as possible therapeutic strategies.
摘要
缺血性脑再灌注可以减轻损伤并改善预后，但由于炎症机制引起的继发性损伤限制了此类中风治疗的疗效和时间窗。本综述总结了缺血性损伤中炎症的细胞和分子基础以及可能的治疗策略。
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本文引用的文献
1
Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice.
Age (Dordr). 2010 Sep;32(3):271-82. doi: 10.1007/s11357-010-9135-y. Epub 2010 Mar 5.
2
Lipoxin A4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion.
Brain Res. 2010 Apr 6;1323:174-83. doi: 10.1016/j.brainres.2010.01.079. Epub 2010 Feb 4.
3
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells.
J Leukoc Biol. 2010 May;87(5):779-89. doi: 10.1189/jlb.1109766. Epub 2010 Feb 3.
4
Inflammatory mechanisms in ischemic stroke: therapeutic approaches.
J Transl Med. 2009 Nov 17;7:97. doi: 10.1186/1479-5876-7-97.
5
Inflammation as a therapeutic target in acute ischemic stroke treatment.
Curr Top Med Chem. 2009;9(14):1240-60. doi: 10.2174/156802609789869619.
6
Emerging roles of PGE2 receptors in models of neurological disease.
Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):104-12. doi: 10.1016/j.prostaglandins.2009.04.003. Epub 2009 Apr 11.
7
Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation.
Brain Behav Immun. 2010 Jul;24(5):708-23. doi: 10.1016/j.bbi.2009.09.010. Epub 2009 Sep 19.
8
Longitudinal changes of defensive and offensive factors in focal cerebral ischemia-reperfusion in rats.
Brain Res Bull. 2009 Aug 14;79(6):371-5. doi: 10.1016/j.brainresbull.2009.05.001. Epub 2009 May 14.
9
Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity.
Brain Res. 2009 Jul 7;1279:168-73. doi: 10.1016/j.brainres.2009.05.020. Epub 2009 May 14.
10
Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts.
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