Suppr超能文献

症状性 Schatzki 环扩张后的长期复发率。

Long-term recurrence rates following dilation of symptomatic Schatzki rings.

机构信息

Department of Gastroenterology, Deutsche Klinik für Diagnostik, Aukammallee 33, 65191, Wiesbaden, Germany.

出版信息

Dig Dis Sci. 2011 May;56(5):1432-7. doi: 10.1007/s10620-010-1427-7. Epub 2010 Oct 26.

Abstract

BACKGROUND AND AIMS

This study investigated the long-term clinical course of patients with Schatzki rings, who were treated by single bougie dilation. Furthermore, it analyzed possible predictors for the time of recurrence.

PATIENTS AND METHODS

A total of 133 patients (100 males, 33 females) with a mean age of 57 ± 14.6 years who were treated by single dilation with the use of Maloney bougies without the aid of fluoroscopy were prospectively registered and followed-up for a mean duration of 58.3 months (range 12-240 months). Duration of remission was evaluated by Kaplan-Meier estimates with regard to recurrence. Log-rank test was performed to analyze possible predictors for the time to second dilation (recurrence).

RESULTS

No complications occurred and all patients were symptom-free at the first follow-up examination 4 weeks after dilation. However, later on, 73 patients required a second dilation. The estimate remission rates were 63.8% (95% CI: 55.6-72.0%) after 2 years, 44.3% (95% CI: 35.4-53.4%) after 5 years, and 39.9% (95% CI: 30.5-49.3%) after 10 years. Neither the initial morphological findings, nor age or gender determined the need for repeated dilation. Only patients treated with a large bougie diameter (≥52 F) seemed to have a tendency for a longer time until symptomatic recurrence.

CONCLUSIONS

Single dilation of symptomatic Schatzki rings is a safe and effective therapy. However, more than half of the patients will need a second treatment. Recurrences are unrelated to initial morphological findings, age, or gender. Only the treatment with a large bougie diameter (≥52 F) showed a tendency for a longer time of remission.

摘要

背景与目的

本研究旨在探讨经单次探条扩张治疗的 Schatzki 环患者的长期临床病程,并分析复发时间的可能预测因素。

方法

共前瞻性登记并随访了 133 例(男 100 例,女 33 例)接受单纯扩张治疗的患者,平均年龄为 57 ± 14.6 岁,使用 Maloney 探条,无需透视。平均随访时间为 58.3 个月(范围 12-240 个月)。通过 Kaplan-Meier 估计来评估缓解持续时间与复发之间的关系。对数秩检验用于分析第二次扩张(复发)时间的可能预测因素。

结果

无并发症发生,所有患者在扩张后 4 周的首次随访检查时均无症状。然而,后来有 73 例需要进行第二次扩张。2 年后的估计缓解率为 63.8%(95%可信区间:55.6-72.0%),5 年后为 44.3%(95%可信区间:35.4-53.4%),10 年后为 39.9%(95%可信区间:30.5-49.3%)。初始形态学发现、年龄或性别均不能决定是否需要重复扩张。只有接受较大探条直径(≥52 F)治疗的患者似乎有更长的无症状复发时间。

结论

经单次探条扩张治疗有症状的 Schatzki 环是一种安全有效的治疗方法。然而,超过一半的患者需要第二次治疗。复发与初始形态学发现、年龄或性别无关。只有接受较大探条直径(≥52 F)治疗的患者显示出更长的缓解时间。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验