利用点击功能化聚合物胶囊靶向癌细胞。

Targeting of cancer cells using click-functionalized polymer capsules.

机构信息

Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.

出版信息

J Am Chem Soc. 2010 Nov 17;132(45):15881-3. doi: 10.1021/ja106405c. Epub 2010 Oct 26.

DOI:10.1021/ja106405c

PMID:20977221

Abstract

Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targeting offers promise for drug delivery applications.

摘要

靶向药物递送到特定的细胞，可以将高治疗剂量递送到靶位点，同时最小化有害的副作用。将靶向分子与纳米工程药物载体（如聚合物胶囊、胶束和聚合物囊泡）结合，具有显著提高一系列药物的治疗输送和指数的潜力。我们提出了一种使用点击化学将低污染的纳米工程聚合物胶囊功能化的通用方法。我们证明，即使靶细胞在总细胞群体中不到 0.1%，抗体（Ab）功能化的胶囊也可以特异性地结合结直肠癌细胞。这种精确的靶向为药物输送应用提供了希望。