Department of Ophthalmology, Shiraz University of Medical Sciences, Khalili Hospital, Shiraz, Iran.
J Ocul Pharmacol Ther. 2011 Feb;27(1):17-21. doi: 10.1089/jop.2010.0094. Epub 2010 Oct 26.
The aim of this study was to evaluate the effect of subconjunctival bevacizumab on early postoperative wound healing in patients with primary pterygium excision.
In this randomized, double-blind, placebo-controlled study, the patients were randomized into 2 groups. Group 1 (G1) received a total of 7.5 mg bevacizumab (5 mg/0.2 mL on the day of surgery and 2.5 mg on the fourth day after surgery). Group 2 received 0.2 mL balanced salt solution at the end of surgery. Postoperatively, patients were examined at 1 day, 1 week, and 1 month. The following parameters were evaluated: horizontal length of the corneal epithelial defect (in millimeters), conjunctival erythema, conjunctival flap edema, subconjunctival hemorrhage, lacrimation, and photophobia. Any complications of conjunctival flaps such as retraction and melting or wound infection were recorded.
There were no statistically significant differences for age, sex, operated eye, and horizontal size of pterygium among 44 eyes of 44 patients, 22 in each group. No patient had conjunctival flap melting or retraction, keratitis, or nonhealing corneal epithelial defect. No statistically significant differences were observed between the groups for the evaluated measures except for conjunctival erythema at the first postoperative day (P = 0.005), which was more common in G1. Although the horizontal length of corneal epithelial defect in G1 was twice that of group 2 on the seventh postoperative day (average 0.09 vs. 0.04 mm, range 0-1 vs. 0-0.3 mm), the difference was not statistically significant (P = 0.45).
No adverse effect on early postoperative wound healing of excised primary pterygium was observed in patients who received subconjunctival bevacizumab.
本研究旨在评估原发性翼状胬肉切除术后结膜下注射贝伐单抗对早期伤口愈合的影响。
在这项随机、双盲、安慰剂对照研究中，患者被随机分为 2 组。第 1 组（G1）共接受 7.5mg 贝伐单抗（手术当天 5mg/0.2mL，术后第 4 天 2.5mg）。第 2 组在手术结束时给予 0.2mL 平衡盐溶液。术后第 1 天、第 1 周和第 1 个月对患者进行检查。评估参数如下：角膜上皮缺损的水平长度（毫米）、结膜充血、结膜瓣水肿、结膜下出血、流泪和畏光。记录结膜瓣的任何并发症，如回缩和融解或伤口感染。
44 例 44 眼中，2 例各 22 眼，年龄、性别、手术眼和翼状胬肉体部大小在两组间无统计学差异。无患者出现结膜瓣融解或回缩、角膜炎或角膜上皮缺损不愈合。除第 1 天结膜充血外（P=0.005），两组评估指标无统计学差异，G1 更常见。尽管第 1 天 G1 的角膜上皮缺损的水平长度是第 2 组的两倍（平均 0.09 对 0.04 毫米，范围 0-1 对 0-0.3 毫米），但差异无统计学意义（P=0.45）。
在接受结膜下贝伐单抗治疗的原发性翼状胬肉切除术后患者中，未观察到对早期伤口愈合的不良影响。
