Gazi University School of Medicine, Department of Medical Oncology, Ankara, Turkey.
Expert Opin Pharmacother. 2010 Nov;11(16):2715-25. doi: 10.1517/14656566.2010.523699.
Breast cancer is one of the leading causes of cancer-related deaths in the world. Despite the significant improvements in the adjuvant treatment strategies of early-stage breast cancer, many patients experience relapse. Bisphosphonates are widely used in the treatment of bone metastasis of solid tumors and multiple myeloma, as well as in osteoporosis. The results of clinical studies of adjuvant treatment on early-stage hormone-receptor-positive breast-cancer patients under hormonal treatment - especially with the bisphosphonate zoledronic acid - caused excitement because they demonstrated an additive effect on decreasing disease relapses at bone or other sites. A number of clinical and in vitro and in vivo preclinical studies, which are either ongoing or have just ended, are investigating the mechanisms and antitumoral activity of bisphosphonates.
The current literature on the preclinical and clinical studies into antitumoral effect and adjuvant treatment of bisphosphonates, especially zoledronic acid, are summarized. Data in the literature over the last two decades were also reviewed.
The reader will find a summary of preclinical and clinical studies of antitumoral effect and adjuvant treatment with bisphosphonates, in particular zoledronic acid, as well as ongoing trials about adjuvant treatment of breast cancer with zoledronic acid and ibandronate.
Current evidence supports zoledronic acid as an effective treatment in adjuvant breast-cancer therapy for hormone-receptor-positive breast-cancer patients when added to hormonotherapy. Uncertainty about effects of zoledronic acid and other bisphosphonates will be clarified after completion of ongoing trials.
乳腺癌是全球癌症相关死亡的主要原因之一。尽管早期乳腺癌辅助治疗策略有了显著的改进，但许多患者仍会复发。双膦酸盐广泛用于治疗实体瘤和多发性骨髓瘤的骨转移以及骨质疏松症。在接受激素治疗的早期激素受体阳性乳腺癌患者的辅助治疗（特别是使用双膦酸盐唑来膦酸）的临床研究结果令人兴奋，因为它们显示出在减少骨或其他部位疾病复发方面具有附加作用。许多正在进行或刚刚结束的临床和体外及体内临床前研究正在研究双膦酸盐的作用机制和抗肿瘤活性。
本文总结了双膦酸盐（特别是唑来膦酸）在抗肿瘤作用和辅助治疗方面的临床前和临床研究的最新文献。还回顾了过去二十年来文献中的数据。
读者将了解到双膦酸盐（特别是唑来膦酸）的抗肿瘤作用和辅助治疗的临床前和临床研究的总结，以及关于唑来膦酸和伊班膦酸盐辅助治疗乳腺癌的正在进行的试验。
目前的证据支持在激素治疗的基础上添加唑来膦酸作为激素受体阳性乳腺癌患者辅助乳腺癌治疗的有效治疗方法。在完成正在进行的试验后，将明确唑来膦酸和其他双膦酸盐的效果。
