Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan.
Acta Paediatr. 2011 Mar;100(3):466-8. doi: 10.1111/j.1651-2227.2010.02071.x. Epub 2010 Nov 17.
We report a case of X-linked agammaglobulinemia complicated with endobronchial tuberculosis.
We observed the patient's clinical course and analysed his data retrospectively.
Interestingly, the T-cell proliferation activity in this patient was intact, and the CD4-positive T cells produced interferon gamma. However, the result of the quantiferon alpha-2b test was negative.
The findings of this case suggest that the quantiferon alpha-2b test may not be diagnostic for tuberculosis not only in patients with T-cell disorders but also in cases with B-cell deficiencies such as X-linked agammaglobulinemia.
我们报告一例 X 连锁无丙种球蛋白血症并发支气管内膜结核。
我们观察了患者的临床过程，并对其数据进行了回顾性分析。
有趣的是，该患者的 T 细胞增殖活性完整，CD4 阳性 T 细胞产生干扰素 γ。然而，α-2b 干扰素检测结果为阴性。
该病例提示，α-2b 干扰素检测不仅对 T 细胞疾病患者，而且对 X 连锁无丙种球蛋白血症等 B 细胞缺陷患者的结核病诊断可能都不适用。
