Department of Cardiology, Cardiovascular Research Institute Maastricht University Medical Center, Maastricht, Netherlands.
Thromb Haemost. 2011 Jan;105(1):122-30. doi: 10.1160/TH10-06-0363. Epub 2010 Oct 26.
Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-β1 (TGF-β1) was completely inhibited immediately after training (p<0.01), and remained so after four weeks recovery. Likewise, monocyte chemoattractant protein-1 (MCP-1)-induced migration declined after training (p<0.01) and improved only partially during the recovery period. MCP-1 serum levels were significantly reduced after four weeks recovery compared to baseline (p<0.01). Total blood antioxidant capacity was enhanced at this time point (p<0.01). Monocyte chemokinesis, TGF-β1 and nitric oxide serum levels remained unchanged during the study. Strenuous three-week training consisting of repeated exercise bouts in healthy, sedentary individuals reduces monocyte chemotaxis. It remains to be established, whether this is a sound adaptation to increased stimuli or an untoward reaction to overtraining. Nevertheless, the effect remains for several weeks with no exercise.
体育锻炼对心血管功能和疾病预防很重要，但它可能会影响免疫系统。我们评估了剧烈运动对单核细胞趋化性的影响。从 13 名年轻、健康、久坐的个体的血液中分离出单核细胞，这些个体参加了为期三周的训练计划，该计划包括反复运动。在基线、三周训练后和四周恢复期调查了单核细胞趋化性和血清生物标志物。血管内皮生长因子-A（VEGF-A）和转化生长因子-β1（TGF-β1）的趋化性在训练后立即完全抑制（p<0.01），并在四周恢复期后仍保持不变。同样，单核细胞趋化蛋白-1（MCP-1）诱导的迁移在训练后下降（p<0.01），并且仅在恢复期部分改善。与基线相比，在四周恢复期后 MCP-1 血清水平显著降低（p<0.01）。此时总血液抗氧化能力增强（p<0.01）。单核细胞趋化性、TGF-β1 和一氧化氮血清水平在研究期间保持不变。在健康、久坐的个体中，为期三周的剧烈运动训练包括反复运动，会降低单核细胞趋化性。目前尚不清楚这是对增加刺激的合理适应还是过度训练的不利反应。然而，在没有运动的情况下，这种影响会持续数周。
