Döcke W D, Volk H D, von Baehr R
Institut für Medizinische Immunologie, Humboldt-Universität zu Berlin.
Allerg Immunol (Leipz). 1990;36(4):209-23.
Heat shock proteins (HSP) or stress proteins are produced by prokaryotic and eukaryotic cells in response to a variety of environmental stressors. The heat shock response is one of the most universal reactions known and heat shock proteins are among the most conserved molecules in phylogeny. Recent findings concerning the immune response to heat shock proteins are discussed especially with respect to the role of HSPs postulated in septic disease and inflammation, in antipathogenic immunity and in the induction of autoimmune diseases. Results and speculations considering a relationship between HSPs and gamma/delta T cells or polyreactive antibodies, possibly as part of a phylogenetic old immune system, are critically reviewed.
热休克蛋白（HSP）或应激蛋白由原核细胞和真核细胞产生，以应对各种环境应激源。热休克反应是已知最普遍的反应之一，而热休克蛋白是系统发育中最保守的分子之一。本文讨论了关于热休克蛋白免疫反应的最新发现，特别是关于热休克蛋白在败血症和炎症、抗病原体免疫以及自身免疫性疾病诱导中所假定的作用。对热休克蛋白与γ/δT细胞或多反应性抗体之间关系的结果和推测进行了批判性综述，这可能是系统发育古老免疫系统的一部分。
