Block R I, Ghoneim M M, Kumar V, Pathak D
Department of Anesthesia, University of Iowa, Iowa City.
Anesth Prog. 1990 Nov-Dec;37(6):271-6.
The subjective effects of nitrous oxide were examined by administering questionnaires to volunteers (16 men and 16 women) breathing 30% nitrous oxide or 100% oxygen. Nitrous oxide produced a variety of subjective effects, including some that are characteristic of psychedelic drugs, such as happy, euphoric mood changes, changes in body awareness and image, alterations of time perception, and experiences of a dreamy, detached reverie state. The subjective effects, including those of a psychedelic nature, were very similar to the subject effects we observed in a previous study of nitrous oxide. However, euphoric mood changes were more pronounced, and adverse effects were less pronounced, in the present study, possibly due to the shorter duration of gas inhalation or the minimal tests of performance involved. Some other differences in subjective effects between the present and previous studies were identified by a discriminant analysis and seemed related to specific differences in experimental conditions. This suggests that the environment can influence which drug effects emerge, or at least their relative prominence. Clinicians should be familiar with the range of subjective effects that patients inhaling nitrous oxide may experience.
通过向吸入30%氧化亚氮或100%氧气的志愿者（16名男性和16名女性）发放问卷，研究了氧化亚氮的主观效应。氧化亚氮产生了多种主观效应，包括一些迷幻药物特有的效应，如愉悦、欣快的情绪变化、身体感知和形象的变化、时间感知的改变，以及梦幻般、超脱的遐想状态体验。这些主观效应，包括那些具有迷幻性质的效应，与我们之前在一项氧化亚氮研究中观察到的主观效应非常相似。然而，在本研究中，欣快的情绪变化更为明显，不良反应则不那么明显，这可能是由于气体吸入时间较短或所涉及的性能测试最少。通过判别分析确定了本研究与之前研究在主观效应上的一些其他差异，这些差异似乎与实验条件的具体差异有关。这表明环境可以影响哪些药物效应会出现，或者至少影响它们的相对突出程度。临床医生应该熟悉吸入氧化亚氮的患者可能经历的主观效应范围。
