Garrison R J, Kannel W B, Feinleib M, Castelli W P, McNamara P M, Padgett S J
Atherosclerosis. 1978 May;30(1):17-25. doi: 10.1016/0021-9150(78)90149-1.
High density lipoproteins were measured on fasting blood samples from 4107 men and women. Control for reported alcohol consumption and subscapular skinfold thickness using multiple regression analysis allowed an examination of the relationship between cigarette smoking and HDL cholesterol. Cigarette smoking was found to be associated with an average difference in HDL cholesterol of about 4 mg/dl in men and 6 mg/dl in women. Furthermore, when heavy alcohol drinkers were eliminated a significant negative association between number of cigarettes smoked and HDL cholesterol was demonstrable in both men and women. There was no evidence that former cigarette smokers, with the exception of those who switched to cigars or pipes or had quit less than one year, had lower HDL levels. Cigar or pipe smokers who had never smoked cigarettes had alcohol- and skinfold-adjusted HDL cholesterol comparable to the non-smoker. These observations indicate another possible link between inhaled tobacco smoke and the atherosclerotic process and suggest the need for further studies and experiments that might clarify the mutual relationship of HDL cholesterol, cigarette smoking and the atherosclerotic process.
对4107名男性和女性的空腹血样进行了高密度脂蛋白检测。通过多元回归分析对报告的饮酒量和肩胛下皮褶厚度进行控制后，得以研究吸烟与高密度脂蛋白胆固醇之间的关系。结果发现，吸烟与男性高密度脂蛋白胆固醇平均相差约4毫克/分升、女性相差约6毫克/分升有关。此外，排除重度饮酒者后，男性和女性的吸烟量与高密度脂蛋白胆固醇之间均呈现出显著的负相关。没有证据表明，除了转而吸食雪茄或烟斗或戒烟不到一年的人之外，既往吸烟者的高密度脂蛋白水平较低。从未吸过香烟的雪茄或烟斗吸烟者，其经酒精和皮褶调整后的高密度脂蛋白胆固醇与不吸烟者相当。这些观察结果表明吸入的烟草烟雾与动脉粥样硬化进程之间可能存在另一种联系，并表明需要进一步开展研究和实验，以阐明高密度脂蛋白胆固醇、吸烟与动脉粥样硬化进程之间的相互关系。
