Cui Yong, Zong Xu-Yi, Hao Shu-Yu, Zhang Ya-Zhuo
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 10050, China.
Zhonghua Yi Xue Za Zhi. 2010 Jun 15;90(23):1622-4.
To explore the diagnosis and microsurgical treatment of giant cell tumor (GCT) of skull.
The investigators reviewed the clinical features, operative approach and prognosis of 23 consecutive cases of GCT of skull operated at our department between July 2000 and November 2008.
Headache was the most common presenting symptom (86.96%) found among the patients with GCT of skull. Besides, the symptoms induced by the consequent lesions of II-XII intracranial nerves were also commonly observed. The mean duration of symptoms was 29.3 months and the mean preoperative KPS (Karnofsky performance scale) was 76 +/- 6. Among these cases, 10 tumors occurred in sphenoid bone, 9 in temporal bone, 3 in posterior fossa and 1 in frontal bone. Gross total resections were achieved in 6 cases, subtotal resections in 10 cases and partial resections in 7 cases. There was no operative death case. The follow-up data of 18 patients (78.26%) were collected with a mean follow-up duration of 35.5 months. All patients lived in normal postoperative life.
GCT of skull is a generally low-degree malignancy showing a local bone invasion mostly in sphenoid and temporal bones.
探讨颅骨骨巨细胞瘤（GCT）的诊断及显微外科治疗方法。
回顾性分析2000年7月至2008年11月在我科手术治疗的23例连续颅骨GCT患者的临床特征、手术方式及预后。
头痛是颅骨GCT患者最常见的首发症状（86.96%）。此外，由Ⅱ-Ⅻ颅神经继发损害引起的症状也较为常见。症状平均持续时间为29.3个月，术前平均KPS（卡氏功能状态评分）为76±6。其中，10例肿瘤位于蝶骨，9例位于颞骨，3例位于后颅窝，1例位于额骨。6例实现了全切除，10例次全切除，7例部分切除。无手术死亡病例。收集了18例患者（78.26%）的随访资料，平均随访时间为35.5个月。所有患者术后生活正常。
颅骨GCT一般为低度恶性，主要侵犯蝶骨和颞骨的局部骨质。
