Krantz S, Stelter F, Lober M, Gromoll B
Institute of Biochemistry, Ernst Moritz Arndt University, Greifswald, FRG.
Biomed Biochim Acta. 1990;49(12):1237-41.
Complement component 3 (C3) phenotype and allele frequencies were defined in 312 patients with type-1 diabetes (insulin-dependent diabetes mellitus), 256 patients with type-2 diabetes (non-insulin-dependent diabetes mellitus), 114 apparently non-diabetic first-degree relatives of type-1 diabetics, in 10 families (29 members) with a familial history of type-1 or type-2 diabetes, in 181 patients with coronary heart disease and 255 subjects with arterial hypertension. 512 blood donors served as controls. All persons investigated were Europeans. There is no evidence that genes linked to C3 influence susceptibility to type-1 and type-2 diabetes and to their late complications as well as to atherosclerosis and essential hypertension. The distribution of apolipoprotein E phenotypes in patients and controls was likewise not significantly different. The combined evaluation of data from linked genes (C3 and apo E) could not improve the results. Deductions of C3 as a genetic disease marker have to be interpreted with caution.
在312例1型糖尿病（胰岛素依赖型糖尿病）患者、256例2型糖尿病（非胰岛素依赖型糖尿病）患者、114例1型糖尿病明显非糖尿病的一级亲属、10个有1型或2型糖尿病家族史的家庭（29名成员）、181例冠心病患者和255例动脉高血压患者中，确定了补体成分3（C3）的表型和等位基因频率。512名献血者作为对照。所有接受调查的人均为欧洲人。没有证据表明与C3相关的基因会影响对1型和2型糖尿病及其晚期并发症以及动脉粥样硬化和原发性高血压的易感性。患者和对照中载脂蛋白E表型的分布同样没有显著差异。对连锁基因（C3和载脂蛋白E）数据的综合评估并不能改善结果。将C3作为遗传疾病标志物的推断必须谨慎解释。
