Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. i.reiss @ erasmusmc.nl
Neonatology. 2010;98(4):354-64. doi: 10.1159/000320622. Epub 2010 Oct 27.
Congenital diaphragmatic hernia (CDH) is associated with high mortality and morbidity. To date, there are no standardized protocols for the treatment of infants with this anomaly. However, protocols based on the literature and expert opinion might improve outcome. This paper is a consensus statement from the CDH EURO Consortium prepared with the aim of achieving standardized postnatal treatment in European countries. During a consensus meeting between high-volume centers with expertise in the treatment of CDH in Europe (CDH EURO Consortium), the most recent literature on CDH was discussed. Thereafter, 5 experts graded the studies according to the Scottish Intercollegiate Guidelines Network (SIGN) Criteria. Differences in opinion were discussed until full consensus was reached. The final consensus statement, therefore, represents the opinion of all consortium members. Multicenter randomized controlled trials on CDH are lacking. Use of a standardized protocol, however, may contribute to more valid comparisons of patient data in multicenter studies and identification of areas for further research.
先天性膈疝（CDH）与高死亡率和高发病率相关。迄今为止，对于患有这种异常的婴儿，还没有标准化的治疗方案。然而，基于文献和专家意见的方案可能会改善结果。本文是 CDH EURO 联合会的一份共识声明，旨在实现欧洲国家标准化的产后治疗。在具有 CDH 治疗专业知识的高容量中心之间的共识会议期间（CDH EURO 联合会），讨论了 CDH 的最新文献。此后，5 名专家根据苏格兰校际指南网络（SIGN）标准对研究进行了分级。在达成完全共识之前，对不同意见进行了讨论。因此，最终的共识声明代表了所有联合会成员的意见。关于 CDH 的多中心随机对照试验仍然缺乏。然而，使用标准化方案可能有助于在多中心研究中更有效地比较患者数据，并确定进一步研究的领域。
