Pten 基因敲低导致 Pten(shRNA) 小鼠多种器官发生肿瘤。
Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice.
机构信息
Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA.
出版信息
Cancer Biol Ther. 2010 Dec 1;10(11):1194-200. doi: 10.4161/cbt.10.11.13814.
Abstract
To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly, and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.
摘要
为了研究 Pten 部分缺失对肿瘤起始的影响，我们构建了 PtenshRNA 小鼠，其中在各种组织中 PTEN 表达水平降低到正常水平以下。PtenshRNA 小鼠经常发生淋巴样和前列腺增生、脾肿大和皮脂腺腺瘤。我们的观察结果支持这样一种观点，即 shRNA 部分降低 Pten 的剂量足以在多个器官系统中诱导肿瘤疾病。
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