Furukawa-Hibi Yoko, Nitta Atsumi, Fukumitsu Hidefumi, Somiya Hitomi, Furukawa Shoei, Nabeshima Toshitaka, Yamada Kiyofumi
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan.
Neuroreport. 2010 Dec 29;21(18):1177-81. doi: 10.1097/WNR.0b013e3283411685.
Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.
小突触泡蛋白是化学突触活性区的组成成分之一，可调节突触小泡的运输。小突触泡蛋白C2A结构域是一种重要的钙传感器，可与磷脂酰肌醇或突触结合蛋白-1结合。最近，临床研究表明，小突触泡蛋白C2A结构域中的单核苷酸多态性可能是重度抑郁症的一个致病风险因素。为了阐明小突触泡蛋白与抑郁症的关联，我们制备了过表达小突触泡蛋白C2A结构域的转基因小鼠，并对这些小鼠的行为进行了研究。这些小鼠在强迫游泳和悬尾试验中均表现出抑郁样行为，表明小突触泡蛋白可能调节抑郁行为。
