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10 价肺炎球菌/流感嗜血杆菌蛋白 D 结合疫苗加强免疫接种同时接种 DTPw-HBV/Hib 和脊髓灰质炎疫苗的安全性和免疫原性。

Safety and immunogenicity of a booster dose of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine coadministered with DTPw-HBV/Hib and poliovirus vaccines.

机构信息

Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang, Muntinlupa City, Philippines.

出版信息

Pediatr Infect Dis J. 2011 Jan;30(1):69-72. doi: 10.1097/INF.0b013e3181f2da06.

DOI:10.1097/INF.0b013e3181f2da06
PMID:20980933
Abstract

The safety and reactogenicity profiles of the 10-valent pneumococcal conjugate vaccine, PHiD-CV, and 7vCRM were comparable within the Philippines and Poland when coadministered as a booster dose with DTPw-HBV/Hib and poliovirus vaccines to toddlers primed with the same vaccines. Robust immune responses for all 10 vaccine pneumococcal serotypes and protein D following PHiD-CV booster vaccination were indicative of effective priming.

摘要

在菲律宾和波兰，当作为加强针与 DTPw-HBV/Hib 和脊髓灰质炎病毒疫苗联合接种时，10 价肺炎球菌结合疫苗 PHiD-CV 和 7vCRM 的安全性和反应原性特征与单独使用时相似，这些疫苗已用于为幼儿进行初免接种。在接受 PHiD-CV 加强针接种后，所有 10 种疫苗型肺炎球菌和蛋白 D 均产生了强大的免疫应答，表明初免接种效果良好。

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