Deane Drug Discovery Institute, Duke University, Durham, North Carolina, USA.
Clin Pharmacol Ther. 2010 Dec;88(6):867-70. doi: 10.1038/clpt.2010.246. Epub 2010 Oct 27.
Genetics as a discipline is fundamental for the pharmaceutical industry; it contributes to all therapeutic areas and has an impact throughout the research and development continuum, right up to and including clinical practice. Pharmacogenetics is seen as a significant contributor to increasing the efficiency and effectiveness of pharmaceutical R&D, and it enhances the growing interest in personalized medicine. This article discusses some contemporary issues that influence drug development and examines the potential of pharmacogenetics to reduce the risk and uncertainty that are inherent in the drug development process.
遗传学作为一门学科，对制药行业至关重要；它涵盖了所有治疗领域，并对整个研发过程产生影响，直至包括临床实践。药物遗传学被视为提高药物研发效率和效果的重要因素，也增强了人们对个性化医疗日益增长的兴趣。本文讨论了一些影响药物开发的当代问题，并探讨了药物遗传学降低药物开发过程中固有风险和不确定性的潜力。
