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公牛睾丸后精子的成熟变化:附睾小体和前列腺小体的重要作用。

Post testicular sperm maturational changes in the bull: important role of the epididymosomes and prostasomes.

作者信息

Caballero Julieta, Frenette Gilles, Sullivan Robert

机构信息

Département d'Obstétrique-Gynéologie, Faculté de Médecine, Centre de Recherche du Centre Hospitalier de l'Université Laval (CHUQ), Université Laval, 2705 Boulevard Laurier, T1-49, Quebec City, QC, Canada G1V 4G2.

出版信息

Vet Med Int. 2010 Oct 13;2011:757194. doi: 10.4061/2011/757194.

DOI:10.4061/2011/757194
PMID:20981306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2958493/
Abstract

After spermatogenesis, testicular spermatozoa are not able to fertilize an oocyte, they must undergo sequential maturational processes. Part of these essential processes occurs during the transit of the spermatozoa through the male reproductive tract. Since the sperm become silent in terms of translation and transcription at the testicular level, all the maturational changes that take place on them are dependent on the interaction of spermatozoa with epididymal and accessory gland fluids. During the last decades, reproductive biotechnologies applied to bovine species have advanced significantly. The knowledge of the bull reproductive physiology is really important for the improvement of these techniques and the development of new ones. This paper focuses on the importance of the sperm interaction with the male reproductive fluids to acquire the fertilizing ability, with special attention to the role of the membranous vesicles present in those fluids and the recent mechanisms of protein acquisition during sperm maturation.

摘要

精子发生后,睾丸精子无法使卵母细胞受精,它们必须经历一系列成熟过程。这些重要过程的一部分发生在精子通过雄性生殖道的过程中。由于精子在睾丸水平上翻译和转录方面处于静止状态,它们发生的所有成熟变化都依赖于精子与附睾和附属腺液的相互作用。在过去几十年中,应用于牛种的生殖生物技术有了显著进展。公牛生殖生理学知识对于改进这些技术和开发新技术非常重要。本文重点关注精子与雄性生殖液相互作用以获得受精能力的重要性,特别关注这些液体中存在的膜性小泡的作用以及精子成熟过程中蛋白质获取的最新机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85af/2958493/130394d2ef33/VMI2011-757194.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85af/2958493/f0f205982d97/VMI2011-757194.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85af/2958493/130394d2ef33/VMI2011-757194.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85af/2958493/f0f205982d97/VMI2011-757194.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85af/2958493/130394d2ef33/VMI2011-757194.002.jpg

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Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes.不同生育指数公牛去污剂提取精子蛋白的蛋白质组学比较。
Reproduction. 2010 Mar;139(3):545-56. doi: 10.1530/REP-09-0375. Epub 2009 Dec 1.
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Sci Rep. 2024 Jun 28;14(1):14925. doi: 10.1038/s41598-024-65950-0.
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The evolving roles of extracellular vesicles in embryo-maternal communication.细胞外囊泡在胚胎-母体通讯中的不断演变的作用。
Commun Biol. 2024 Jun 21;7(1):754. doi: 10.1038/s42003-024-06442-9.
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Int J Mol Sci. 2023 Feb 6;24(4):3194. doi: 10.3390/ijms24043194.
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