Xu H Q
Department of Biophysics, Shanghai Medical University.
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Dec;23(6):345-7, 384.
The clinical and neuropathologic findings in 11 cases with intracerebral hemorrhages related to CAA were reported. Their age ranged from 45 to 79 years, the average being 61.8 years. The hematomas were all in cerebral lobes, except two patients whose hematomas were in the basal ganglia and thalamus. These hematomas were in irregular shapes, ruptured into ventricles and/or subarachnoid space in all cases. The vessel's wall of arteries in the leptomeninges, superficial cortex and those adjacent to hemorrhagic foci showed considerable thickness. Hemorrhagic foci showed considerable thickness. Homogeneously eosinophilic structures deposited in these vessel's wall of several small arteries. Some of these vessels showed luminal stenosis. Congo red staining confirmed characteristic amyloid apple-green birefringence under polarizing microscope.
报告了11例与脑淀粉样血管病（CAA）相关的脑出血患者的临床和神经病理学发现。他们的年龄在45至79岁之间，平均年龄为61.8岁。血肿均位于脑叶，仅有2例患者的血肿位于基底节和丘脑。这些血肿形状不规则，所有病例均破入脑室和/或蛛网膜下腔。软脑膜、浅表皮质及出血灶附近动脉的血管壁明显增厚。出血灶也明显增厚。在几条小动脉的血管壁中沉积有均匀嗜酸性结构。其中一些血管出现管腔狭窄。刚果红染色在偏振显微镜下证实有特征性的淀粉样蛋白苹果绿双折射。
