Koleva M, Donchev N, Borov B, Dzharova V
Eksp Med Morfol. 1990;29(4):57-61.
The results from morphological studies on liver, lung, heart, spleen, intestine, brain, skin, testes (ovaries), obtained in the end of the first and third month of animals, treated with pharmapentoxiphyline (PP), are described. The experiments were carried out on 312 white rats (male and female), divided into 2 series: I series--oral usage of the preparation in doses of 100, 300 and 6 mg/kg, II series--intraperitoneal administration in doses of 30, 75 and 150 mg/kg. It was established that PP, administered for a period of 3 months orally in a dose of 100 mg/kg and intraperitoneally in a dose of 30 mg/kg did not induced changes in the structure of all examined organs. Slight dystrophic changes in liver, lung and spleen occurred in the end of the third month under the influence of an oral dose of 300 mg/kg and an intraperitoneal dose of 75 mg/kg. The obtained results are discussed in connection with the pharmacological action of drug-peripheral vasodilatator.
描述了在动物第一个月和第三个月末，对用戊氧苯茶碱（PP）治疗的肝脏、肺、心脏、脾脏、肠道、大脑、皮肤、睾丸（卵巢）进行形态学研究的结果。实验在312只白色大鼠（雄性和雌性）上进行，分为2组：第一组——以100、300和6mg/kg的剂量口服制剂，第二组——以30、75和150mg/kg的剂量腹腔注射。结果表明，以100mg/kg的剂量口服3个月和以30mg/kg的剂量腹腔注射3个月的PP，并未引起所有检查器官结构的变化。在口服300mg/kg剂量和腹腔注射75mg/kg剂量的影响下，第三个月末肝脏、肺和脾脏出现了轻微的营养不良性变化。结合药物外周血管扩张剂的药理作用对所得结果进行了讨论。
