Puri S K, Sharma P, Dutta G P
J Commun Dis. 1990 Jun;22(2):98-101.
The pattern of sequential relapses in 10 rhesus monkeys following inoculation of sporozoites of Plasmodium cynomolgi B has been studied after administering curative dose of chloroquine (5 mg/kg base X 7 days) to eliminate blood parasitaemia after each relapse. Observation for periods ranging from 109 to 245 days showed that the interval between first six relapses was 19.3 +/- 6.77 days (1st relapse), 20.9 +/- 8.43 days (2nd relapse), 22.8 +/- 8.55 days (3rd relapse), 27.8 +/- 10.0 days (4th relapse), 31.67 +/- 11.50 days (5th relapse) and 32.5 +/- 16.26 days (6th relapse). The results of this study indicate a gradual extension of the relapse interval in successive relapses.
在给10只恒河猴接种食蟹猴疟原虫B的子孢子后，每次复发后给予治疗剂量的氯喹（5mg/kg碱×7天）以消除血液中的寄生虫血症，之后研究了其连续复发的模式。109至245天的观察表明，前六次复发之间的间隔分别为19.3±6.77天（第一次复发）、20.9±8.43天（第二次复发）、22.8±8.55天（第三次复发）、27.8±10.0天（第四次复发）、31.67±11.50天（第五次复发）和32.5±16.26天（第六次复发）。本研究结果表明，连续复发时复发间隔逐渐延长。
