[诱导性全脊髓阻滞下的体循环变化及血管升压药的选择]
[Changes in systemic circulation under induced total spinal block and choice of vasopressors].
作者信息
Kobori M, Negishi H, Masuda Y, Hosoyamada A
机构信息
Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
出版信息
Masui. 1990 Dec;39(12):1580-5.
Total spinal block by using 2% lidocaine 0.5 ml.kg-1 (10.0 mg.kg-1) was carried out in adult mongrel dogs. The effects of atropine 0.02 mg.kg-1, isoproterenol 0.5 mcg.kg-1, methoxamine 0.1 mg.kg-1 and ephedrine 0.5 mg.kg-1 to counteract circulatory changes by total spinal block were studied. Atropine did not exert any marked influence on circulatory system. Isoproterenol elevated HR, LV dp/dt max and CI temporarily, but did not decrease MAP and SVR. Methoxamine elevated MAP and SVR, but decreased CI. Ephedrine is a drug of choice for this situation because it elevated HR, MAP, LV dp/dt max and SVR.
对成年杂种犬使用2%利多卡因0.5 ml·kg⁻¹（10.0 mg·kg⁻¹）进行全脊髓阻滞。研究了0.02 mg·kg⁻¹阿托品、0.5 μg·kg⁻¹异丙肾上腺素、0.1 mg·kg⁻¹甲氧明和0.5 mg·kg⁻¹麻黄碱对抗全脊髓阻滞引起的循环变化的效果。阿托品对循环系统未产生任何显著影响。异丙肾上腺素可使心率、左心室dp/dt max和心脏指数暂时升高，但未降低平均动脉压和全身血管阻力。甲氧明使平均动脉压和全身血管阻力升高，但降低了心脏指数。麻黄碱是这种情况的首选药物，因为它能升高心率、平均动脉压、左心室dp/dt max和全身血管阻力。
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