Takeda S, Inada Y, Tashiro N, Matsui K, Tomaru T, Negishi H, Hosoyamada A
Department of Anesthesiology, Showa University, Fujigaoka Hospital, Yokohama.
Masui. 1990 Dec;39(12):1586-96.
Hemodynamic features of hypotension induced by nicardipine were studied in 18 mongrel dogs under 0.87% halothane in oxygen (1MAC). They were randomly allocated to one of two groups. Group C received no vasodilator therapy and served as control and group N received infusion of nicardipine. Mean arterial pressure decreased and was maintained at 60 mmHg for 60 minutes in group N. No change was noted in hemodynamic variables measured in group C throughout the experiment. During and after induced hypotension in group N, cardiac index (CI), stroke volume index (SVI), central venous pressure (CVP), and right ventricular stroke work index (RVSWI) increased significantly compared with the control values. On the other hand, systemic vascular resistance (SVR) was significantly reduced, reaching 25% of the control value at the end of hypotension period. Heart rate showed a progressive increase but not significantly. Left ventricular maximum dp/dt showed a moderate increase during hypotension, but then decreased gradually to the control value after induced hypotension. Left ventricular stroke work index (LVSWI) and pulmonary vascular resistant (PVR) were unchanged from the control value during and after induced hypotension. The data indicate that nicardipine is a potent systemic vasodilator with hyperdynamic hemodynamic effects in addition to significant increase in right ventricular function.
在18只杂种犬吸入0.87%氟烷（1MAC）加氧气的条件下，研究了尼卡地平诱导低血压的血流动力学特征。它们被随机分为两组。C组未接受血管扩张剂治疗作为对照组，N组接受尼卡地平输注。N组平均动脉压下降并维持在60 mmHg达60分钟。整个实验过程中，C组所测血流动力学变量无变化。在N组诱导低血压期间及之后，与对照值相比，心脏指数（CI）、每搏量指数（SVI）、中心静脉压（CVP）和右心室每搏功指数（RVSWI）显著增加。另一方面，全身血管阻力（SVR）显著降低，在低血压期末降至对照值的25%。心率呈逐渐增加但无显著变化。左心室最大dp/dt在低血压期间有中度增加，但在诱导低血压后逐渐降至对照值。诱导低血压期间及之后，左心室每搏功指数（LVSWI）和肺血管阻力（PVR）与对照值无变化。数据表明，尼卡地平是一种强效的全身血管扩张剂，除了显著增加右心室功能外，还具有高动力性血流动力学效应。
