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[某些特定定义指标对成人急性非淋巴细胞白血病完全缓解和生存的预后价值:一种预后评分系统的建议]

[Prognostic usefulness of certain defined indicators for achieving complete remission and survival of ANLL in adults: proposal of a prognostic scale].

作者信息

Krzemień S, Hołowiecki J, Jagoda K, Hołowiecka B

机构信息

Kliniki Hematologii Sl. AM w Katowicach.

出版信息

Pol Tyg Lek. 1990;45(51-52):1032-6.

PMID:2098741
Abstract

Retrospective analysis has included 323 patients with acute nonlymphocytic leukaemia. The comparable patient groups were treated since 1981, according to protocols used by the Polish Acute Leukaemia Group. The prognostic value for achieving complete remission and survival of 67 pre-treatment factors (42 quantitative and 25 qualitative) was evaluated. The most important 9 parameters were scored according to their prognostic value as follows: age, percent of blasts in bone marrow, peripheral blood blast count, morphological subtype, percent of granulocytes in bone marrow, percent of blasts with CD-15 antigen, thrombocyte count, spleen/liver enlargement, CSF protein levels. Proposed scoring system enables classification of ANLL patients to a standard and high risk groups.

摘要

回顾性分析纳入了323例急性非淋巴细胞白血病患者。自1981年起,根据波兰急性白血病研究组使用的方案对可比患者组进行治疗。评估了67个预处理因素(42个定量因素和25个定性因素)对实现完全缓解和生存的预后价值。根据其预后价值对最重要的9个参数进行评分如下:年龄、骨髓中原始细胞百分比、外周血原始细胞计数、形态学亚型、骨髓中粒细胞百分比、表达CD-15抗原的原始细胞百分比、血小板计数、脾/肝肿大、脑脊液蛋白水平。所提出的评分系统能够将急性非淋巴细胞白血病患者分为标准风险组和高风险组。

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