Meier-Sydow J, Kronenberger H
Abteilung für Pneumologie, Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
Z Gesamte Inn Med. 1990 Oct 1;45(19):589-92.
Disseminated pulmonary diseases sensu stricto are interstitial lung disorders, pulmonary edema, diffuse pulmonary bleeding as well as bronchiolitis obliterans and thrombo-embolic disorders. Three important pathogenetic mechanisms are direct toxicity, allergy/immunology and idiosyncrasy; however, unfrequently essential elements of pathogenesis are unknown. The multitude of potential noxious agents implies that the clinician principally has to consider the possibility of drug-toxicity in all cases of disseminated pulmonary diseases. In order to give a complete presentation summaries organized as tables could not be avoid. The most sensible measure for disseminated lung diseases is the functional parameter DLCO; it is more sensible than the conventional X-ray. The drug of choice for a treatment are corticosteroids.
狭义的播散性肺部疾病包括间质性肺疾病、肺水肿、弥漫性肺出血以及闭塞性细支气管炎和血栓栓塞性疾病。三个重要的发病机制是直接毒性、过敏/免疫学和特异反应性；然而，发病机制中不常见的基本要素尚不清楚。众多潜在的有害物质意味着临床医生在所有播散性肺部疾病病例中主要都必须考虑药物毒性的可能性。为了进行完整的阐述，不可避免地要以表格形式进行总结。对于播散性肺部疾病最敏感的指标是功能参数一氧化碳弥散量（DLCO）；它比传统的X线检查更敏感。治疗的首选药物是皮质类固醇。
