Dragomir D, Popescu V
Clinica de Pediatrie, Spitalul Clinic Sf.Pantelimon, Bucureşti.
Pediatrie (Bucur). 1992 Jul-Sep;41(3):36-45.
The problem of the drug induced pulmonary toxicity (cytotoxic and non-cytotoxic drugs) is discussed. This domain of modern pathology is in continuous development, although yet insufficiently delineated. The essential pathogenic mechanisms are presented as well as the main histopathological lesions (i.e., interstitial pneumonia and pulmonary fibrosis). The usual lesional aspects specific to certain drugs are also reviewed. For the principal chemical substances in this category, the clinical and radiological aspects are given, also the various treatment indicated, the evolution and the prognosis of the drugs induced pulmonary disease.
本文讨论了药物性肺毒性（细胞毒性和非细胞毒性药物）问题。现代病理学的这一领域仍在不断发展，尽管尚未得到充分界定。文中介绍了主要的致病机制以及主要的组织病理学病变（即间质性肺炎和肺纤维化）。还回顾了某些药物常见的特定病变表现。对于该类主要化学物质，阐述了其临床和放射学表现、各种治疗方法、药物性肺病的病情发展及预后。
